Domingo Francisco Sánchez (b. 20 March 1795 in Asunción, d. 1 March 1870) was the Vice President of Paraguay in the administration of Francisco Solano López from 1862 to 1870. Sánchez was one of the few officials who worked in the administrations of Gaspar Rodríguez de Francia, Carlos Antonio López and Francisco Solano López.
He died in the War of the Triple Alliance in combat with Brazilian forces on 1 March 1870.
| Preceded by Francisco Solano López |
Vice President of Paraguay 1862-1870 |
Succeeded by Cayo Miltos |